Job Description

POSITION:   Research Associate/Senior Research Associate – Discovery platform biology

**Candidacy Submission will not be considered complete unless a resume is accompanied by a cover letter specifically detailing candidate's experience with mammalian cell culture. Please combine your CV and cover letter into a single file to upload.

Would you like to discover next-generation medicines? Join Rgenta! Rgenta is an innovative, venture-backed biotechnology company located in the Greater Boston area, and we are growing our biology team as we expand our efforts to develop new therapeutics. At Rgenta Therapeutics, our goal is to unlock the therapeutic potential of disease-causing targets that have been undruggable by traditional approaches by using our proprietary RNA-targeting platforms. This platform has been developed by leveraging our deep knowledge in data-driven genomics, computational biology, high-throughput screening, and medicinal chemistry.

Our Target Biology group seeks a motivated cell and molecular biologist to help the team launch new therapeutic discovery programs. Our ideal candidate is someone with strong scientific curiosity, a drive for innovation, and a passion for drug discovery. This role requires keen attention to detail with excellence in experimental design and execution to generate decision-enabling datasets. In collaboration with a multi-disciplinary team of scientists, the successful candidate will be a key contributor to the drug discovery process by characterizing promising targets for our discovery platform. This position will provide the candidate with the unique opportunity to involve their creative assay development skills and support the discovery of pharmacological agents that modulate pre-mRNA processing.

ROLE RESPONSIBILITIES:

• Generate and maintain genetically modified cellular models of human disease. 
• Develop and optimize cell-based assays for  in vitro pharmacology in high-throughput formats.
• Pilot and execute automated molecular biology workflows that generate critical data to support our platform.
• Diligent maintenance of an electronic lab notebook in addition to presentation of research plans and datasets to company peers and leadership.

BASIC QUALIFICATIONS:

• BS or MS degree in biology or pharmacology-related discipline, or equivalent industrial experience.
• Minimum 1-2 years of relevant research experience in an academic, biotech or pharmaceutical laboratory.
• Broad experience with aseptic technique and mammalian cell and tissue culture methods including stable cell line generation.
• Proficiency with standard molecular and cell biology techniques (e.g. RT-qPCR, Western blotting, plasmid cloning).
• Excellent communication and prior success in a collaborative, team-based research environment.

DESIRED QUALIFICATIONS:

• Past research involving RNA biology, pre-mRNA processing, and/or RNA splicing.
• Hands-on experience generating cell lines using viral transduction and/or genome editing.
• Experience developing and validating cell-based or biochemical assays to support drug discovery.
• Familiarity with the process of adapting experimental workflows to laboratory automation such as liquid handling systems, washers, and multi-modal microplate readers.

Rgenta is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

• Competitive medical, dental, and vision plans
• Flexible Spending Accounts for medical and dependent care
• Free Peloton app and Apple Fitness+ access
• Weight loss programs with personalized coaching
• Employee Assistance Program for mental health, legal, and financial support
• Paid family leave
• Generous paid time off including vacation, sick days, and holidays
• 401(k) program
• Stock options for eligible employees
• Education assistance programs
• Access to exclusive rewards for wellness activities

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit: Join Us | Rgenta Therapeutics (rgentatx.com) to learn more about our current opportunities.

Rgenta is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Rgenta is proud to be an equal opportunity workplace and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

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