The Beck lab in the Center for Human Genetics and Genomics at the New York University Grossman School of Medicine is seeking highly motivated and talented candidates for fully funded postdoctoral positions starting Summer 2025.
Our group is interested in understanding the genetic determinants of disease and utilizing this information to define the mechanisms underlying pathologic processes. We use a combination of patient derived samples, mouse and cellular models, and in vitro biochemical tools to dissect these pathways. Our major focus is on characterizing autoinflammatory diseases, or diseases of constitutive activation of the innate immune system, frequently caused by genetic mutations. In particular our recent discovery of VEXAS Syndrome (Vacuoles, E1, X-linked, Autoinflammatory, Somatic Syndrome) a severe inflammatory disease affecting hundreds of thousands of individuals, that is caused by somatic mutations in UBA1, highlights the power of integrating clinical studies, human genetics, and molecular biology to uncover previously unrecognized pathways and diseases. We are looking for postdocs with expertise in any of these fields (immunology, cell signaling, mouse models, biochemistry, experimental pharmacology) to join our new lab and lead a stimulating project.
Some of our previous published work can be found below:
– Beck DB et al. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease. N Engl J Med. 2020 Dec 31;383(27):2628-2638. doi: 10.1056/NEJMoa2026834. Epub 2020 Oct 27. PMID: 33108101; PMCID: PMC7847551.
-Collins JC et al. Shared and distinct mechanisms of UBA1 inactivation across different diseases. EMBO J. 2024 May;43(10):1919-1946. doi: 10.1038/s44318-024-00046-z. Epub 2024 Feb 15. PMID: 38360993; PMCID: PMC11099125.
-Ferrada MA et al. Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis. Blood. 2022 Sep 29;140(13):1496-1506. doi: 10.1182/blood.2022016985. PMID: 35793467; PMCID: PMC9523373.
The Beck lab is part of the vibrant NYU School of Medicine Campus located in the heart of Manhattan. In addition, NYU offers postdoctoral scholars with competitive benefits, subsidized housing in New York City, and many career development opportunities. More information can be found here:
Prospective candidates should email an application package to Dr. Beck containing a CV and a short cover letter describing your expertise and research interest. Applications will be reviewed on a rolling basis.
Contact:
Dr. David Beck
Center for Human Genetics and Genomics
New York University Grossman School of Medicine
David.Beck@nyulangone.org
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